William J. Mack
William J. Mack

Associate Professor of Neurological Surgery (Clinical Scholar)
Director, Neurointerventional Program, Keck Hospital of Usc
Director, Neurosurgery Ambulatory Services, Keck Medical Center of Usc

William Mack, MD, received his bachelor degree with honors from Cornell University. He then attended Columbia University, College of Physicians and Surgeons, where he graduated from medical school and completed Neurosurgical residency training. During residency, he spent one year performing a post-doctoral cerebrovascular research fellowship under Drs. David J. Pinsky and E. Sander Connolly Jr. at Columbia University. Following residency, Dr. Mack completed an Interventional Neuroradiology fellowship at UCLA.

Dr. Mack's major areas of clinical interest are stroke, brain aneurysms, subarachnoid hemorrhage, arteriovenous malformations (AVMs), arteriovenous fistulas, cavernous malformations, carotid artery disease, intracranial stenosis, and brain tumors. Dr. Mack performs both open surgery and minimally invasive, endovascular procedures for cerebrovascular disorders.

Dr. Mack is the Principal Investigator and Director of the Cerebrovascular Laboratory in the Zilkha Neurogenetic Institute. He has received numerous local, regional, and national grants in support of his research efforts. Dr. Mack's scientific interests are focused on translational efforts to treat ischemic and hemorrhagic stroke. Laboratory investigations concentrate on the pathophysiology of stroke and inflammatory modulation. Using the information and experience gained in the laboratory, Dr. Mack is working to develop new technologies, techniques, and therapies to directly improve the clinical care administered to stroke patients.


  • Neurological Surgery
    • Endovascular Neurosurgery
  • Interventional Radiology


General Surgery - Columbia University College-Physicians & Surgeons
Interventional Neuroradiology - UCLA Medical Center
Neurological Surgery - Columbia University College-Physicians & Surgeons
Medical School
Columbia University College of Physicians and Surgeons